This is my truth, I don’t know if it is true for anyone else. Before I write anything more I could have one of those disclaimers that I see on other blogs, but I hope it is obvious that I am writing a personal blog and nothing more. We are all experts when it comes to ourselves aren’t we?
When I wrote Everything I Know (Almost)…about depression, it was true to say that was pretty much all I felt confident about. Since writing that page, about 40 posts ago, I have asked many questions, talked to many people, and listened… more than anything I have listened.
In my last post, I shared a link to the following You Tube film, which has a running time of about an hour and features Professor Robert Sapolsky, a neuroscientist, giving a lecture on the subject of depression at Stanford University : Stanford's Sapolsky on Depression in the US (Full Lecture). For me, it provided an unparalleled insight into depression. I wish someone had sat me down and introduced me to this lecture years ago. Fortunately I have science in my background, and in my blood, so I found the lecture fairly easy to follow; Sapolsky is skilled at pitching it just right. But I appreciate that isn’t going to be the case for everybody; after all science wasn’t everybody’s favourite subject at school.
I imagine that others out there have found themselves questing as I have. I have depression; I live in a world where our popular understanding of this condition is clouded by ignorance and prejudice (understandably); and where the fragments of understanding I have collected from health professionals have felt like pieces of a jigsaw… only they don’t seem to come from the same box. I am serious about getting better, and I know I am fortunate in that attitude because my motivation for getting better stems from my relationships with other people. Not everybody is so fortunate to have the company of a supportive family – my broad family of choice. But I have said it before and I say it again now… a powerful ingredient in overcoming depression is ‘other people’, not because of the advice the can offer or what they can do for you, but because we are all the same just enough to feel compassion for each other and show each other kindness, and kindness is healing, not just in a poetic sense but in a biochemical sense.
A word about where I’m coming from. I don’t believe in science. Science is not a belief system. It is a way of understanding the world and explaining the way it works based on what we know and understand so far, given the tools we have to explore that world. However... scientific knowledge and understanding is but a dot on a very long time line hurtling towards the future… and as we travel that way, we learn more, we learn differently and our understanding shifts and improves. I accept this. Science is not faith, it should not be followed as people follow faiths… it thrives on being questioned and challenged, it does not seek to preserve itself, it evolves and it is hungry to one day arrive at a holistic picture of the world, some way to explain everything without its own internal contradictions. It is a long way from achieving this. There are good faiths with helpful messages, as there is good science too, and both worlds are susceptible to human flaws - in particular … ego. So when I form opinions on both, I try and separate out the body of knowledge and understanding from the people and the inevitable trappings of being human. History is full of stories about good faiths corrupted by our human flaws. We have done much harm in the name of religion… but I don’t blame religion… we are at once amazing human beings and only human at the same time. So for me, science is not itself a culprit for past tragedies either.
Major depression is not the ups and downs of daily life, and unfortunately taking that experience and extrapolating it… magnifying it… does not provide a better sense of what major depression feels like. So those of us with depression can feel frustrated that others seem to misunderstand and underplay the difficulties we are experiencing. And sometimes we see that others are frustrated by us, because we depressives don’t seem to bounce back and ‘cope’ like other people do.
It is clear though that there are several different components to depression. There is a reason why the jigsaw pieces seem to come from different boxes.
Of the many chemical messengers (neurotransmitters) used by our brains to communicate from one neurone to the next… a few are presently known to be implicated in depression. In simple terms, lacking in these particular neurotransmitters inhibits our ability to experience pleasure, brings on strong feelings of guilt and grief, and slows down our thinking and our movements. Unpack that, and for me this meant I could no longer feel the warmth of other people’s love; my mood was no longer instantly lifted by the things I used to enjoy like the dawning of a warm sunny day and a Monet sky; I couldn’t hear the sweet uplifting sound of my 3 year old’s laughter or feel the presence of my adoring dogs. Without willing it and unable to stop it I relived every misfortunate memory of failure and loss, every conversation, every awkward moment, and in doing so I felt utterly hopeless and responsible. I cried; felt an intense sadness that made the muscles hang from by bones, and withdrew into an impenetrable silence. The mundane activities of daily life like taking a shower, putting on clothes, grooming, preparing food, brushing teeth and exercising all became difficult, sometimes even impossible. I’d get confused easily, squint with concentration as I tried to follow conversations, seize up at the challenge of having to make even simple decisions. I felt stupid and self conscious around other people, especially at work.
So lacking certain neurotransmitters seems to have a pretty serious and noticeable effect on day to day life, so much so that it left me feeling like I was barely living at all. There are those that quite rightly argue that we cannot actually measure the quantities of these neurotransmitters in the brain before, during or after treatment. However it doesn’t then follow that the science about neurotransmitters is all nonsense. Antidepressants are big business and that often attracts conspiracy theorists, which is no bad thing… but I have yet to hear anyone argue against the way that Cocaine acts on our neural pathways in the way that I hear arguments against antidepressants.
There were times I wished I had cancer instead. I know that isn’t a good thing to say, but it is how I felt at the time. Even cancer sufferers seem to be able to know pleasure through the pain of their illness and in doing so are able to summon up the fight in themselves. Depression left me without the capacity to feel ‘fight’, and then like so many others, without the will to live.
It is common these days to be prescribed an antidepressant known as a selective serotonin reuptake inhibitor (SSRI). As the name suggests, these work by inhibiting the reuptake of one particular neurotransmitters, serotonin, and so raising levels of this chemical messenger in the brain. SSRIs became popular amongst health professionals because they carried fewer side effects than their predecessors, and perhaps more significantly are safer in overdose than traditional antidepressants. It is well known that antidepressants carry a warning of “the symptoms of depression may worsen before the antidepressant can take effect. For some people, this may include thoughts of suicide or self-harm.” I think this creates confusion and takes away from the credibility of antidepressants to treat depressive symptoms. After all, if antidepressants are supposed to make you feel better, why might they increase your risk of suicide? However, I certainly recall that in those darkest of days that whilst I wanted to take my life I had little mental or physical energy to do so. It was only when I started to improve under the influence of antidepressants, and regained motivation and thinking that I could start to become serious about suicide. Recovery periods pose a greater risk of suicide that those days when we are confined to our bed sleeping the days away.
So SSRIs work by raising the levels of available serotonin reaching our receptors at the synapses, where one neuron meets another. However, serotonin, albeit a very major player and a workhorse amongst neurotransmitters, is only one such chemical messenger implicated in depression. Older classes of antidepressants increased levels of three different neurotransmitters, serotonin, norepinephrine and dopamine. All three are known to be implicated in depressive symptoms. Whilst raising levels of serotonin would alleviate feelings of grief and guilt, working on dopamine would reawaken our feelings of pleasure and motivation, aid with sleep, attention and memory, whilst norepinephrine would help restore physical activity. Understanding this goes some way towards understanding why for many of us, SSRIs like Fluoxetine do not provide the magic bullet we might hope for.
Then we have to consider a psychological component, as I have many times before in this blog, given difficulties that arise from the design of our human brain. To understand these difficulties is to begin to understand why it can be so difficult to be human at times, and also appreciate why we are so spectacularly different to the rest of the animal kingdom. Human beings have evolved sophisticated ‘new’ brains, the regions we refer to as the cortex, involved in memory, attention, perceptual awareness, thought, language, and consciousness, that have to work alongside some much ‘older’ areas of the brain that do more mundane and functional things. We have old animal instincts and drives, developed to survive a harsher world of food scarcity and hungry predators; systems that respond quickly to a world of potential threats. The flip side is that our mechanical responses to the world can be triggered by, not just real world threats, but by ‘imagined’ threats. I like the way Sapolsky describes it when he says that “our cortex whispers into the ear of our middle brain and triggers a stress response as thought we were about to be gorged by an elephant”.
I came to learn about the psychological component in more depth through therapy. I learned that my unmanaged thoughts are capable of activating responses in equal measure to real world threats. I learned that some of my childhood experiences, lived out in those impressionable years left their imprint on the design of my brain along with the genetic blueprints I inherited… and together they sowed the seeds of negative thinking that would hijack me in later life. It is possible, when we are moulding our young brains, to turn these old and useful survival mechanisms inwards and onto ourselves so we feel unsafe, insecure and in doing so destroy our self worth.
Through cognitive behaviour therapy (CBT), I slowly learnt about how my childhood experiences were connected to the deep feelings of worthlessness that I had spent a lifetime trying to conceal from others. I began to see why perfectionisms was so important to me, and why I would need to break with this forceful habit. I had developed a whole life around protecting myself and hiding from others my dark truth that I was, underneath it all, nothing. Simplistically, perfectionism had been a way of elevating myself above the criticisms of others and in doing so, escaping detection.
Like an alcoholic having to look in the mirror at their own troubled face and say to that person “I have a problem”, I realised I needed help. With Judy, I learnt to tap into the negative automatic thoughts. At first it was very hard… the new brain, the cortex, would conjure its negative thoughts and whisper to midbrain with it powers for emotion, and it would respond … and just as quickly the ‘old’ hind brain would shape a physical response. In reality, I would only really be aware of the feelings like fear or embarrassment at first. Later I would learn to see how they were affecting me physically, notice the way my body crumpled from the impact with these emotions or how I would flee the scene. Later still I would learn to reflect on these events to identify the negative automatic thought, the mean things that my cortex was whispering much of the time to make me feel so emotionally battered. It would take more time still to learn how to catch these negative automatic thoughts as they popped into existence, rather than let them flow unfiltered into my midbrain and shape my emotions. Catching negative thoughts turned into challenging them… and eventually I would learn to reject them quickly. I might then feel an emotional falter, as my mean thoughts shot there way into the emotion centres of the brain… but I was now able to pull things back into shape quickly, in the blink of an eye and more importantly, behind the scenes without others realising the inner struggle. What would once have triggered a response that had the potential to send me into another depressive episode now became little more than a cognitive stumble.
When a major depression hit again, I was surprised. I understood the links between childhood experiences, my own unhelpful beliefs about myself (core beliefs) and they way these connected with my negative automatic thoughts. So why was I now experiencing another depression. I had overcome perfectionism with remarkable success. So what was this unhelpful habit that now shaped my daily life in unhealthy ways? More looking in the mirror and eventually I had the courage to see it; my dependence on others for approval. Perfectionism was not cause, it was symptom, and underlying it was this pulped self-esteem still fighting to conceal itself. My question to Judy, can I change my core beliefs… is it possible to trade in the feeling that I am worthless for something else? Judy’s reply, that isn’t certain… but what is possible is to change our ‘rules for living’.
As I understand it, once I had at my core some unhelpful beliefs about myself… I also constructed a life that allowed me to ‘cope’ with these beliefs. If I was worthless, I would need to conceal it, I would need to better and out perform others, I would need to work hard at being interesting, I would need to work harder than other people. The rules I had for myself were forming at some point in my past, in my subconscious. They propelled me through life, the hard boss in my head that saw me through achievement after achievement. I was usually the youngest on the team, the youngest consultant, the youngest assistant principal… it was a drive that others would have found unfathomable and maybe even a little bit frightening.
As life gets more complicated and the circles I moved in changed, living by my private rules became more difficult. It isn’t something I could realise at the time. I wasn’t conscious of any of these processes… I was just victim to them. Being infallible, and the best, having the highest standards… would become impossible to maintain. And as I failed to be these things, as the rules I had for myself were broken one by one, the cortex would start whispering its dissatisfaction to the middle brain, starting an emotional uprising and triggering a stress response in the old brain as thought my life itself was in danger.
The head teacher at a school I worked at didn’t believe in stress…that makes her a bit of a dinosaur. Stress, is our bodies’ biochemical and subsequently physical response to something in our environment that might pose a threat…don’t think paperwork… think big hungry mouths ready to turn you into a meal. It’s a reaction characterized by a release of adrenaline preparing you to either fight the threat or run from it, and a release of the hormone cortisol to up your blood sugar (muscle fuel), turn on access to other reserves of energy like fats, and almost shut down your immune system to divert your efforts into reacting. Stress is a brilliant reaction used by other mammals to great effect when faced with the threat of a predator, or some other immediate danger. The old and direct wiring of the hind brain wastes no time in responding to threats… saving vital seconds and possibly the difference between survival and death. We are designed to have a stress response… it is no bad thing in itself. When we take an exhilarating ride on a roller coaster or jump with nothing but a bungee cord between us and death, we are tapping into that stress response and enjoying the rush of chemicals it brings. When we are expecting a rush and get it… it is a pleasure. Feeling a stress response when we are not expecting it, by contrast can cause anxiety, panic maybe anger and all those uncomfortable feelings I’m sure you know only too well.
Sadly, for us human beings, the whisperings of the cortex can trigger a stress response too. When my rules for living were broken, when I believed I had fallen short or exposed a weakness, I’d tell myself how I’d failed… beat myself mentally. A stress response that was designed to react in a moment to immediate threats can be kept in play unnaturally by the constant whisperings of the cortex. Prolonged stress, what is called chronic stress, a prolonged biological response, not to a hungry lion, but the threats that originated from the way I viewed the world, and myself in it. It is like a madness isn’t it; well at least if lions could talk I think that’s what they would say.
The ingredients for major depression were present. A family history with undiagnosed depression, early childhood stressors, some unhelpful core beliefs, some hard rules for living, and all they needed to blend them was an activator… a stressor… I had started to live a life where being the ‘me’ I had constructed became impossible, and the flaws I saw in myself were becoming difficult to conceal. As I failed, and each day felt myself failing a little more… the stress was building and being sustained. I have since come to learn that for me, stress, be it from an external or internal stressor, can leave the door open for depression.
Stress was to become another component of depression that I had never considered before. Just beneath the surface I was becoming aware of the link between stress and depression. In this most recent episode of depression I chose to withdraw from work and other responsibilities. It wasn’t that I was working and decided to stop whilst I got better. It was that even though I couldn’t work, mentally I gave myself a hard time about it. When I did choose to take a break and told myself ‘it’s ok, I’m not expecting you to be anywhere or to do anything’ the mental punishment stopped and I could start to concentrate on getting better. It made a huge difference and was key to speeding up my recovery. Doctors will often sign off patients in the midst of a major depression, but it took me a long time to understand how to use that time to get better. I remember previous episodes where being away from work was mental torture, endless feelings of guilt and failure revolving around not being at work. Had I given myself permission to be away, as my GP had done, I suspect I would have healed much sooner. Instead I was generating and sustaining a stress response that made it impossible for my health to improve.
I realised that if I could manage stress more effectively, I could also manage and maybe even avert future episodes of depression. Clearly, the way I lived my life was not the only way to live. This is a big planet, and there are many ways to live out our time on it. It is easy to get caught up with the way people do things on our little square of the Earth and think that that is how life is to be lived, but that just isn’t so. The big decisions I had made like leaving my career in education, I didn’t realise until later, had been attempts to control and manage stress in my life. I started to look deep into myself and figure out my own values, because I was realising that the bit of the world I occupied was full of stress and played to the drives and dissatisfactions of the old brain. Fine if you are not me with my baggage, but not fine for me.
In fact, I started to realise that internal and external stressors were two separate components that could contribute to depression. It isn’t like this all over the planet, but certainly in my part of the world people are encouraged to be driven by a few things. There is the God drive to work, the belief that God wants us to work, work hard and frowns upon idleness (which is anything that isn’t working). That somehow working is bound to our morals. There is the illusion that employers everywhere use to make employees feel like they belong and that company values have brought meaning and purpose to their lives. That we are taking part in some bigger project for the good of humanity. That we should be passionate about our work. There is the drive to avoid going hungry, and more commonly there is the drive to just buy more stuff. I’m not even sure it’s about owning any of it anymore… it is more about the buying. I think many of us recognise this world, and it is a relentless and persuasive world. If I am to make decisions for the good of my health, I had better learn how to tell myself I don’t really need that second TV. Managing stress would involve more than just managing my self critical thinking: it would involve keeping this world at arms length and inviting it in on my own terms.
Suddenly, I was starting to realise why some people turned to meditation and other such devices to control their relationship with the wider world and its stresses.
Through a fellow blogger, I became interested in a study carried out by Professor Robert Sapolsky on the subject of stress. For more than 30 years he visited a group of baboons and studied them, using extracted blood samples to investigate their individual levels of stress. Baboons organise themselves into hierarchical troops and his study of these baboons showed that the higher your position in the troop, the lower your levels of stress. Another quite separate study looked at stress levels in another hierarchical system, the British Civil Service. It came to the same conclusions. So for whatever reason, those at the top of the hierarchy experienced lower levels of stress.
Now, if you take your average person off the street and suddenly tell them they are in charge, I imagine there will be some that leap at the chance, and there will be some that freeze with panic… in other words experience a stress response at the very thought. The difference, I think, would be in people’s attitudes. It isn’t that you are at the top and therefore feel less stressed. It is because you feel you are at the top and so feel less stressed. Alicia tells me she read an interview with comedian Eddie Izzard recently and the story fits here so I’ll tell it. Eddie is often asked what it is like to be a transvestite and how other people react. I gather he finds this line of questioning a little bit dull, but anyway he plays along and says that well, if you walk into a room dressed as a woman and say ‘can I have a cup of tea please’ they’ll think, right, well, he wants a cup of tea… let’s get him a cup of tea then. If instead I walk in dressed as a woman feeling a little bit sheepish and standing there not know what to say or do, they will look and think ‘oh my God he is dressed as a woman, what should we do, where should we look?’ The point he makes to the interviewer is it is all about being comfortable with yourself, and others will feel comfortable around you.
Hearing about the studies of hierarchical social groups and about Alicia’s Eddie Izzard anecdote reminded me about a little trick I had back at school. When I had some engagement to attend that made me nervous and anxious, I would pretend to myself, say to myself before I walked through the door ‘you are the President of the United States of America’, and with that thought I would enter the room confident and at ease with myself. Attitude is an amazing thing. A little world for the way we interact with the world.
Lately I’ve been trying to start the day a little bit differently. It is the reason I can’t really blog in the morning. I wake up and take myself somewhere relatively calm, and then I meditate. I use the word loosely. I have no training in meditation and I’m not trying to achieve anything with religious motives. But I’ve read about a few techniques and I’ve found them easy to put into practice. One such technique involves just closing my eyes, and concentrating on the feeling of the air moving in and out through my nostrils as I breathe naturally. What happens at first is it gets quite noisy in my head… thoughts start crashing about. I read that this is to be expected, that our minds are ordinarily so busy that when we stop and focus the first thing we become aware of is all their activity.
After a little while my mind quietens and then it seems sort of blank, a blank page that I can write on. Through CBT I learnt to manage negative thoughts, but what I would rather do is not have negative thoughts in the first place. ‘You can change your rules for living’ - that is what Judy said. So with a quietened mind I start to think all sorts of positive things about me. I tell myself about all my good qualities… I am whispering to the middle brain and I feel it starts to flush with a powerful, soothing feeling. I tell myself ‘you are the boss’ and what I mean is that I am indeed the boss of my own life. It is as though I have come full circle from those youthful days reading Nausea and realising that our purpose in life is not predestined, and the greatest secret and biggest fear is that actually we have choice, freedom… to decide our life’s purpose for ourselves. I tell myself, in this calm meditative state, that I am the boss of my life and then rest there, enjoying the feeling of a smile upon my cheeks.
When I start the day like this, devoting around 15 minutes or so to this small mediation… the rest of the day runs differently, by new rules. I no longer become anxious about what others think, or panic about making it to some place on time, or wonder if I should be doing something else. Instead, I feel an entirely different attitude washing through me. I will get there when I get there. I’ll communicate the situation and they can take it or leave it. I’ll get finished when I get finished, it will take as long as it has too. I decide what I do, and when I do it, it is without the old feelings of pressure, responsibility and guilt. It isn’t that I don’t act responsibly; it is that I do what I do because I want to and choose to, rather than because of the old feelings of I have to. More crucially, Alicia has commented on how much calmer and better I seem, and I feel it too. With a different attitude, what Judy called ‘rules for living’, I am able to operate without the old internal stresses.
I punctuate and reset each morning with a moment of meditation and a shift in attitude, to keep me on the straight and narrow. I aim to travel each day being at ease with myself, being at one with my circumstances, being distant from modern world stresses and being as much in the moment as I can be. Now… I can live this life, or I can keep writing about it. But I can’t do both at the same time. Thank you for reading.

